Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

RK-24466 是一种选择性且有效的 Lck 抑制剂，抑制 Lck (64-509) 和 LckCD 亚型，IC50 分别小于 1 和 2 nM。

PP 3 是 Src 激酶抑制剂 PP 2 的阴性对照。